3,4,5-Trifluorophenylboronic acid is an organoboron building block used in organic synthesis, particularly in Suzuki–Miyaura cross-coupling to form carbon–carbon bonds. Its molecular formula is C6H4BF3O2, and its molecular weight is approximately 175.90 g/mol. The three fluorine atoms are attached to the phenyl ring, while the boronic acid group provides the reactive boron site used in coupling chemistry. At Maison Chemical, we help B2B buyers assess this compound’s identity, documentation, specification requirements, and sourcing fit before placing an order.
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The name identifies a phenylboronic acid substituted with fluorine at the 3, 4, and 5 positions of the aromatic ring. The compound is also identified by CAS RN 143418-49-9. Its structure combines a fluorinated phenyl group with a boronic acid functionality, making it a reagent intended for chemical synthesis rather than a general-purpose material.
The molecular formula, C6H4BF3O2, corresponds to one boron atom, three fluorine atoms, and two oxygen atoms. The molecular weight calculated from this formula is approximately 175.90 g/mol. The fluorine content calculated from the formula is approximately 32.4 wt%; this is a theoretical composition value, not a measured product assay.
For an order intended for research, process development, or manufacturing, the supplier’s current specification and certificate of analysis should be the primary references for product quality. Confirm the stated assay and how it is determined, as well as the identification method and any limits relevant to your application. Do not assume that a value shown in a general chemical listing is identical to the specification for a particular batch.
Physical properties such as appearance, melting range, solubility, and storage conditions should likewise be checked against batch-specific documentation or the supplier’s handling guidance. These details can vary by grade, test method, and product condition. If a particular physical or analytical parameter is critical to your process, include its required method and acceptance limit in your inquiry.
The principal synthetic role of 3,4,5-trifluorophenylboronic acid is as an arylboronic acid coupling partner. In a Suzuki–Miyaura reaction, an organoboron reagent can be coupled with a suitable organic halide or related electrophile in the presence of a catalyst and base. The reaction is widely used to construct carbon–carbon bonds, but performance depends on the specific substrates, catalyst system, reaction conditions, and scale.
In this compound, the aryl group transferred in the coupling carries fluorine substituents at the 3, 4, and 5 positions. This can make the reagent useful when a target molecule requires that particular fluorinated aromatic motif. Researchers may consider it during the preparation of intermediates, candidate molecules, or other compounds in which the substitution pattern is part of the desired structure.
Fluorine substitution changes the electronic and physical characteristics of an aromatic ring compared with an unsubstituted phenyl group. The practical effect on a reaction cannot be predicted from the compound name alone, because substrate structure and conditions also matter. Buyers should therefore evaluate this reagent in the context of their planned transformation and confirm compatibility through appropriate laboratory or process testing.
This product is not interchangeable with phenylboronic acid or with other fluorinated phenylboronic acids that have different substitution positions. A positional change alters the identity of the aryl group introduced during synthesis. When matching an item to a route, verify the complete chemical name, CAS RN, and structure rather than relying only on a broad description such as “trifluorophenylboronic acid.”
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Commercial offers may differ by grade, purity specification, packaging, and documentation. The exact options available should be confirmed for the requested quantity and destination rather than assumed from a generic product description. The following checks help buyers distinguish the requirements that matter for a specific project.
| Specification or document | What to confirm | Why it matters |
|---|---|---|
| Identity | Full chemical name, CAS RN 143418-49-9, and formula | Helps prevent confusion with positional isomers or related reagents. |
| Assay or purity | Acceptance limit, test method, and batch result | Connects the purchased grade to the buyer’s process requirements. |
| Impurity profile | Relevant limits and analytical methods, where specified | Supports internal quality assessment and process evaluation. |
| Handling and packaging | Container size, closure, storage guidance, and transport conditions | Enables safe receipt and appropriate material management. |
| Batch documentation | Certificate of analysis and other available documents | Allows the buyer to review product information before use. |
Begin by defining the intended use, required purity, quantity, and any critical impurity limits. A research group evaluating a reaction may have different acceptance criteria from a buyer supporting a validated manufacturing process. Share the relevant requirements in writing so the supplier can confirm whether the offered grade and available documentation match your needs.
Ask for the current batch certificate of analysis when batch-level results are important. Review the assay basis and analytical method, and clarify whether the reported result is a release test, a typical value, or a guaranteed limit. If your quality system requires additional testing or a specific format, discuss feasibility before order confirmation.
Price, minimum order quantity, lead time, and packaging are order-specific commercial details. They can depend on requested quantity, stock status, production or procurement timing, and delivery destination. Request a written quotation that states the product grade, quantity, packaging, estimated lead time, shipping terms, and validity period so the offer can be compared on a consistent basis.
For international procurement, confirm that the supplier can provide the shipping and product documents required for your company’s import process. Requirements can vary by destination and shipment, so buyers should verify them with their internal compliance or logistics team. If the material is needed for a scheduled synthesis, allow time for document review, shipment planning, and incoming quality checks.
At Maison Chemical, we support B2B inquiries for 3,4,5-trifluorophenylboronic acid by helping buyers clarify the requested identity, grade, quantity, and documentation needs. We can discuss the available product information and provide a quotation subject to current availability and destination requirements. Our aim is to make the commercial and technical scope clear before an order is placed.
To help us respond efficiently, include CAS RN 143418-49-9, your target quantity, required purity or assay limit, destination, and any documentation or packaging requirements. If a specific analytical method or impurity limit is essential, state it in the inquiry rather than treating it as an assumed standard. We can then confirm which requirements can be supported for the requested supply.
3,4,5-Trifluorophenylboronic acid CAS 143418-49-9 is a fluorinated arylboronic acid used primarily as a coupling reagent for carbon–carbon bond formation, especially in Suzuki–Miyaura chemistry. Its molecular formula is C6H4BF3O2, with a formula-based molecular weight of approximately 175.90 g/mol. The three fluorine substituents define the aryl group introduced into a synthesis, so confirming the exact identity is essential.
Before sourcing, compare the offered grade with your process requirements and verify batch documentation, packaging, storage guidance, lead time, and shipping details. Send Maison Chemical your required quantity, destination, and specification criteria to request current product information and a B2B quotation. This gives your team a practical basis for deciding whether the available material fits your project.
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