Pharmacological Actions of Momordica Grosvenori
Momordica grosvenori has high nutritional value, is a kind of longevity fruit, known as ‘immortal fruit’.
Momordica grosvenori has high nutritional value, is a kind of longevity fruit, known as ‘immortal fruit’. Momordica grosvenori is a food and medicine plant, with the fruit into medicine, there are summer moisturising lungs, clearing heat and inflammation, benefit the liver and spleen and other effects.
Momordica grosvenori contains Luo Han Guo Glycosides, protein, a small amount of fat, rich in carbohydrates, dietary fibre, vitamin B2, vitamin C, niacin, as well as calcium, phosphorus, potassium, sodium, magnesium, iron, zinc, selenium and so on. Liquid Monk Fruit Extract has anti-inflammatory, liver protection, improve immunity, as well as lowering blood pressure, lowering blood lipids, help digestion, anti-aging, skin rejuvenation and weight loss.
1. Immune regulation function
Monk fruit extract 25 g/kg, 50 g/kg gavage rats can significantly increase the peripheral blood acidic α-acetate naphthylase-positive lymphocyte percentage, the ratio of specific rosette-forming cells, but does not affect the phagocytosis of peripheral blood neutrophil leukocytes, indicating that Momordica grosvenori has enhanced cellular immunity and humoral immunity function in normal rats, but there is no significant effect on the non-specific immune function of normal rats.
Momordica grosvenori saponins had little effect on the function of macrophages in normal mice, but significantly enhanced the function of cellular and humoral immunity in immunosuppressed mice. Momordica grosvenori saponins can improve the immune function by down-regulating the expression level of IFN-γ and TNF-α factors, changing the ratio of CD4 and CD8 subpopulations of lymphocytes, and increasing the expression level of IL-4 in lymphocytes. Momordica grosvenori polysaccharides can increase the splenic index, thymic index and phagocytosis of macrophages to enhance the immune function of mice. Momordica grosvenori extract can inhibit the activation of nuclear factor NF-к B by interfering with the PI3 K/Akt/IKK and MAPK signalling pathways, thereby down-regulating the expression of macrophage inflammatory factors iNOS and COX-2. Studies have shown that momordica grosvenori III E can attenuate acute lung injury caused by LPS in mice through activation of the TLR4/MAPK/nf-κb axis, and that momordica grosvenori III E can attenuate lung fibrosis through the TOLL-like receptor 4 pathway, suggesting that momordica grosvenori also has a role in immunomodulation.
2. Anti-tumour effect
Momordica grosvenori saponin V can inhibit the development of pancreatic adenocarcinoma by promoting apoptosis, cell G0/G1 phase blockade, reducing microvessel density (MVD) and tumour angiogenesis. At the same time, some studies have shown that momordica grosvenori saponin V in prostate cancer, hepatocellular carcinoma, nasopharyngeal carcinoma, lung cancer, nasopharyngeal carcinoma have a certain inhibition of cancer cell proliferation, in the nasopharyngeal carcinoma cne-1 so that apoptosis-related genes (caspase-3, bax, etc.) expression increases, anti-apoptotic gene (survivin, Bcl-2, etc.) expression decreases, to induce apoptosis, and in the by DMBA or TAP-induced apoptosis. It also had a significant inhibitory effect on the skin cancer model induced by DMBA or TAP. Momordica grosvenori saponin IV E has anticancer effects in laryngeal and colorectal cancers. It was found that Momordica grosvenori saponin IV E could inhibit the proliferation of colorectal and laryngeal cancers through the up-regulation of p53 and the down-regulation of p-ERK 1/2 and MMP-9, which indicated that Momordica grosvenori saponin has antitumour effects.
In addition, the precursor of momordica grosvenori saponin, rosmarinol, also has a certain anti-tumour effect. Studies have shown that momordica grosvenori can inhibit the development of two kinds of tumours by regulating the transport function of P-gp glycoprotein, promoting the G2/M blockade of breast cancer MCF-7 cells induced by ADR, and the apoptosis of oral cancer KB cells induced by VCR. In leukaemia, momordica grosvenori inhibited the phosphorylation of ERK and STAT3 to exert its anti-tumour effect. In addition, momordica grosvenori can inhibit lung cancer by up-regulating the expression of p21, a protein in the A549 cycle of lung cancer cells, which leads to G0/G1 phase block and down-regulates the expression of Bcl-2, an anti-apoptotic protein, in lung cancer cells.
3. Other effects
Momordica grosvenori is often used as a drink in folklore, the aqueous extract of Momordica grosvenori and sweet glycosides of Momordica grosvenori on ammonia or sulfur dioxide-induced cough in mice have obvious inhibitory effect, can increase tracheal phenol red excretion in mice and rat tracheal sputum, and tracheal phenol red excretion, the cough suppressant effect are dose-dependent relationship. Monk fruit extract can inhibit the growth of C-type Streptococcus pyogenes, in which the inhibitory effect of Momordica grosvenori saponin V is very obvious, which makes Momordica grosvenori in the treatment of dental caries has a unique role. Momordica grosvenori extract has a certain anti-fatigue effect, swimming exhaustion experiments show that mogroside in Momordica grosvenori extract has an anti-fatigue effect, and was dose-dependent, the rate of elevation of lactic acid in the blood is slowed down, the level of blood urea nitrogen is reduced, to slow down the onset of fatigue of the body, the testicular tissue of the mice cytochrome C oxidase 7A2 compared with the control group has a significant reduction, indicating that mogroside in Momordica grosvenori extract in the anti-fatigue has a certain role. Momordica grosvenori sweet glycoside has a protective effect on chronic liver injury in rats, and mice immune liver injury, acute liver injury, can effectively reduce the serum AST and ALT activity, can improve the degree of hepatic histopathological changes, so that the homogenate of liver tissue MDA content is reduced, and the activity of SOD is increased.
Momordica grosvenori is a traditional Chinese medicine of the same origin as medicine and food, although it is less used clinically, but its unique sweet flavour makes it popular in the flower tea world for a long time, and its therapeutic dosage is far more than the clinical use of the medicine. Momordica grosvenori as a state-approved dual-use medicinal herbs, its dried fruit has a variety of pharmacological effects, the main active ingredient of triterpene saponins in the cough expectorant, diabetes treatment, immunomodulation, antibacterial, hepatoprotective enzyme, anti-fatigue, anticancer, etc., have a certain role, but the function of the active ingredient of the research has only recently been gradually carried out, with the more and more active ingredients have been isolated and identified and studied, a variety of its pharmacological effects have been developed and are being used for the development of the active ingredient. With more and more active ingredients being isolated and identified and studied, its various pharmacological effects have been developed and widely used in the treatment of diseases.
Are you searching for a monk fruit extract supplier? If so, Get in touch with HZL.